Plasmic Score in Thrombotic Microangiopathy May Not be Discriminatory in Many Instances

thrombotic microangiopathy in iga nephropathy

Thrombotic Microangiopathy in Renal Allografts

The term “thrombotic microangiopathy” (TMA) encompasses non-inflammatory small vessel vasculopathies that are caused by severe endothelial and medial smooth muscle cell injury/necrosis. TMAs can be promoted by a variety of “toxic” stimuli ranging from malignant range hypertension, E. coli infections with bloody diarrhea, radiation, systemic diseases such as scleroderma to iatrogenic events such...

Complement activation in thrombotic microangiopathy.

The endothelium lining the vascular lumen is continuously exposed to complement from the circulation. When erroneously activated on host cells, complement may generate a deleterious effect on the vascular wall leading to endothelial injury, exposure of the subendothelial matrix and platelet activation. In this review the contribution of complement activation to formation and maintenance of the ...

Thrombotic Microangiopathy in IgA Nephropathy

Implication for health policy/practice/research/medical education: Thrombotic microangiopathy (TMA) occurs in IgA nephropathy, but is uncommon in the setting of IgA nephropathy. However, the reports of overlapping morphologic lesions of TMA and IgAN are poorly understood and debatable and needs more attention in larger series of IgAN. Copyright © 2013, Iranian Red Crescent Medical Journal; Publ...

Thrombotic microangiopathy in juvenile dermatomyositis

Objectives and study A 4year-old boy was admitted to our hospital because of progressive proximal muscular weakness of 4 weeks duration, heliotrope rash, erythematous skin lesions in the trunk and limbs and febrile fever. The muscle enzymes were elevated: creatine kinase 7,056 IU/L (0– 170), aldolase 40.3 U/L (0–8), aspartate transaminase 601 U/L (10–37), alanine transaminase 289 U/L (10–37). T...